Which type of diuretic is likely to cause hyperuricemia?

Thiazide diuretics are known to potentially cause hyperuricemia due to their mechanism of action and effect on uric acid metabolism. These diuretics work by inhibiting sodium reabsorption in the distal convoluted tubule of the nephron. This inhibition leads to an increase in the concentration of uric acid in the blood because thiazides can compete with uric acid for secretion and reabsorption in the renal tubules. As a result, the elevated levels of uric acid can lead to hyperuricemia, which is a concern particularly for patients with gout or those at risk of developing gout.

In contrast, loop diuretics typically do not cause hyperuricemia to the same extent, as they primarily inhibit sodium and chloride reabsorption in the loop of Henle, leading to different effects on uric acid handling in the kidneys. Potassium-sparing diuretics do not generally affect uric acid levels significantly, as they usually work at a different site and mechanism, focusing more on potassium retention and sodium excretion. Osmotic diuretics are primarily used to reduce intracranial and intraocular pressure and do not have a notable impact on uric acid levels.

Thus, thiazide