Which of the following is a possible side effect of mannitol?

Mannitol is an osmotic diuretic commonly used to reduce intracranial pressure and treat conditions like oliguric renal failure. One of the significant side effects of mannitol is dehydration. This occurs because mannitol works by drawing water into the renal tubules and increasing urine output. As a result, significant fluid loss can happen, leading to dehydration, especially if fluid intake is not adequately maintained.

When patients are treated with mannitol, careful monitoring of their fluid status is essential to avoid dehydration-related complications. Signs of dehydration can include decreased urine output, dry mucous membranes, and hypotension. The reliance on proper hydration is pivotal when using a diuretic such as mannitol to mitigate these adverse effects.