What medication would raise concern when combined with furosemide (Lasix)?

When considering the use of furosemide, which is a loop diuretic, it's important to understand its interactions with other medications, especially those that can affect renal function. Naproxen sodium, a nonsteroidal anti-inflammatory drug (NSAID), raises specific concerns when combined with furosemide due to its potential to diminish the diuretic's effectiveness.

NSAIDs, including naproxen sodium, can lead to decreased renal blood flow, which can reduce the efficacy of furosemide. This interaction may increase the risk of acute kidney injury, especially in patients who are already at risk or in those where fluid status is precarious. Additionally, the use of NSAIDs alongside diuretics can counteract the intended therapeutic effects of the diuretic due to their effect on kidney function and their ability to retain sodium and water.

While acetaminophen, ibuprofen, and atorvastatin might have their own considerations, they generally do not pose the same level of concern regarding impaired renal function and direct antagonism of furosemide’s effects as seen with naproxen sodium. This understanding highlights the specific pharmacological interactions that require close attention in clinical practice.