What is the effect of furosemide on urine output?

Furosemide is a loop diuretic that is used to increase urine output. It works by inhibiting the sodium-potassium-chloride co-transporter in the ascending loop of Henle in the kidneys. This action prevents the reabsorption of sodium and chloride, which leads to an increase in the osmotic concentration of the tubular fluid. As a result, more water is retained in the nephron, leading to an increased volume of urine produced. This mechanism not only helps in conditions such as edema and hypertension but also plays a crucial role in managing fluid overload in patients with heart failure or renal impairment. Hence, the effect of furosemide on urine output is an increase, making it a valuable agent in diuretic therapy.