What is a potential risk when combining gentamicin with furosemide (Lasix)?

Combining gentamicin with furosemide poses a significant risk of hearing loss, also known as ototoxicity. Both gentamicin and furosemide have the potential to cause damage to the auditory system, particularly the inner ear, which can lead to irreversible hearing impairment. When these two medications are used together, the risk is amplified due to their combined effects on the cochlea and vestibular apparatus of the ear.

Gentamicin, an aminoglycoside antibiotic, is known for its nephrotoxicity and ototoxicity, while furosemide, a loop diuretic, can also have ototoxic effects, especially at higher doses or when used in patients with pre-existing kidney impairment. Therefore, monitoring patients who are prescribed both medications is crucial to mitigate the risk of hearing loss.

The other potential risks listed, such as kidney damage or blood clotting issues, are indeed concerns with these medications, but the specific combination of gentamicin and furosemide is particularly notorious for the risk of ototoxicity.